Exposure to LPHC diets over longer time periods, however,has been associated with increased body weight, adiposity, and fatty liver (Huang et al., 2013; Solon-Biet et al., 2014; Sørensen et al., 2008), indicating that mechanisms for compensa tory energy expenditure may become progressively less effective with time (Huang et al., 2013). Such mice, albeit more adipose, nonetheless have improved cardiometabolic outcomes, including insulin, GTT, HOMA, lipids, and blood pressure (Solon-Biet et al., 2014). It is also important to consider the type of carbohydrate consumed (e.g., starch versus fructose versus glucose [Wylie-Rosett et al., 2004]) as this has been shown in rodent studies to have a profound influence on the development of obesity and insulin resistance

Protein-restricted (PR), high-carbohydrate diets improve metabolic health in rodents, yet the precise dietary components that are responsible for these effects have not been identified. Furthermore, the applicability of these studies to humans is unclear. Here, we demonstrate in a randomized controlled trial that a moderate PR diet also improves markers of metabolic health in humans. Intriguingly, we find that feeding mice a diet specifically reduced in branched-chain amino acids (BCAAs) is sufficient to improve glucose tolerance and body composition equivalently to a PR diet via metabolically distinct pathways. Our results highlight a critical role for dietary quality at the level of amino acids in the maintenance of metabolic health and suggest that diets specifically reduced in BCAAs, or pharmacological interventions in this pathway, may offer a translatable way to achieve many of the metabolic benefits of a PR diet.

Momentan achte ich darauf: mich regional, frisch, zucker- und fettarm und nach Möglichkeit Bio zu ernähren.

Wobei ich mich manchmal frage, wie weit vom Mausmodell wirklich suf den Menschen geschlossen werden kann.